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It has been verified that sKlotho is generated mainly from mKlotho and shed extracellularly by ADAM10 and ADAM17 action

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Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S et al (2015) Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility